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Patent on cymbalta

Patent US5508276 - Duloxetine enteric pellets - Google Patents An enteric duloxetine pellet comprising a) a core consisting of duloxetine and a pharmaceutiy acceptable excipient; b) an optional separating layer; c) an enteric layer comprising hydroxypropylmethylcellulose acetate succinate (HPMCAS) and a pharmaceutiy acceptable excipient; d) an optional finishing layer.11. Cited Patent Filing date Publication date Applicant Title; US4017647 * Jun 9, 1975 Apr 12, 1977 Shin-Etsu Chemical Company Limited

Patent & Regulatory Actions for Duloxetine Cymbalta - YouTube A process for preparing an enteric duloxetine pellet comprising a) providing a core consisting of duloxetine and a pharmaceutiy acceptable excipient; b) optionally, applying to the core a separating layer comprising a pharmaceutiy acceptable excipient; c) applying an enteric layer comprising HPMCAS and a pharmaceutiy acceptable excipient, wherein the HPMCAS is supplied as an aqueous solution or suspension and the application takes place in an apparatus of the fluid bed type; d) optionally, applying a finishing layer. Presentation for the Patents and Regulatory portion of a effort describing Duloxetine aka Cymbalta Life Cycle Strategic Plan Drug.

Patent Register - Drug Products - Health Canada LY248686 (Duloxetine hydrocoride, ( )-N-methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine) was synthesized for research purposes. Patent Register is an alphabetical listing of medicinal ingredients and their associated patents, the patent expiry dates and other related.

Eli Lilly revenue suffers after patent losses for Cymbalta, Evista. An improved process for synthesis of duloxetine hydrocoride (1) having chiral purity greater than 99.9% that is characterized by the following: (i) preparation of racemic condensed compound (RS)—N, N-di methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine (4) by reaction of racemic hydroxy compound (2)..aprotic polar organic solvent in presence of a base selected from sodamide, potassium amide, potassium bis(trimethylsilyl)amide to obtain (RS)—N. The inventors of WO 2004/056,795 have successfully replaced sodium hydride with alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates preferably with potassium hydroxide but the condensation reaction requires to be carried out in presence of phase transfer catalyst such as crown ethers, quaternary ammonium salts, quaternary phosphonium salts to facilitate the reaction. WO 2006/126,213 describe condensation of racemic hydroxy compound with 1-fluoronaphthalene in organic polar solvent such as dimethyl sulfoxide, dimethyl formamide, dimethyl acetamide in presence of alkoxide base such as sodium methoxide, sodium ethoxide and potassium tert. As mentioned above, the alkoxides are very strong bases and hazardous which restrict their use on plant scale reactions. 5,023,269 discloses general method for preparation of (R, S)N, N-dimethyl-3-(1-naphthylenyloxy)-3-(2-thienyl)propanamine (5a 5b) that is isolated as its oxalate salt. Eli Lilly and Co. saw a sharp decline in its first-quarter earnings after recent U. S. patent expirations for two of its best-selling drugs cut sharply.

Generic Cymbalta Availability - Is a drug marketed by Lilly and is included in one NDA. This drug has thirteen patent family members in fourteen countries. There are forty-one drug master file entries for this compound. There are three tentative approvals for this compound. Generic drug availability, manufacturer information, and patent status on Cymbalta

Lilly Targets Actavis In Latest Cymbalta Patent Suit - Law360 Orphan Drug (ODE) - 7 years New Chemical (NCE)- 5 years"Other" Exclusivity - 3 years for a "change" if criteria are met Pediatric Exclusivity (PED) - 6 months added to existing Patents/Exclusivity Patent Challenge – (PC) – 180 days (this exclusivity is for ANDAs only)See 21 C. Eli Lilly and Co. added a fifth generic-drug maker to its bid to block competing versions of its antidepressant Cymbalta Tuesday, suing Actavis.

Duloxetine - pedia Modernizr=function(a,b,c){function C(a)function D(a,b)function E(a,b)function F(a,b)function G(a,b)function H(a,b,d)function I(a,b,c)function J(),s.svg=function(),s.inlinesvg=function();for(var K in s)B(s, K)&&(x=Lower Case(),e[x]=s[K](),v.push((e[x]? Duloxetine, sold under the brand name Cymbalta among others, is mostly prescribed for major. for major depressive disorder, given the hh cost of duloxetine compared to off-patent antidepressants and lack of increased efficacy. Generic.

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